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Effect of HLA-A2 allele disparity on clinical outcome in hematopoietic cell transplantation from unrelated donors.

Morishima Y, Kawase T, Malkki M, Petersdorf EW,

Aichi Cancer Center, Nagoya, Japan. ymorisim@aichi-cc.jp

Population-based differences in clinical outcome after unrelated donor hematopoietic cell transplantation suggest that the significance of human leukocyte antigen (HLA) mismatching may be related to locus-specific and allele-specific differences that distinguish ethnically diverse transplant donors and recipients. We studied the risks associated with HLA-A locus mismatching in two large transplant populations from the International Histocompatibility Working Group in hematopoietic cell transplantation data set to better understand permissible and nonpermissible HLA-A mismatches.

Published 20 April 2007 in Tissue Antigens, 69: 31-5.
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