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Utilization of follow-up specimens from viremic blood donors to assess the value of west nile virus immunoglobulin G avidity as an indicator of recent infection.

Prince HE, Lapé-Nixon M, Busch MP, Tobler LH, Foster GA, Stramer SL

Focus Diagnostics, Cypress, CA 90630, USA. hprince@focusdx.com

The value of West Nile virus immunoglobulin G avidity for distinguishing recent from past infection was investigated using 348 follow-up specimens from 170 viremic blood donors. Low avidity accurately indicated infection within the previous 4 months. However, due to rapid avidity maturation in some individuals, high avidity did not accurately indicate past infection.

Published 8 September 2005 in Clin Diagn Lab Immunol, 12(9): 1123-6.
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